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Dosing of veterinary eye drops 1
Marková, Jana ; Šklubalová, Zdeňka (advisor) ; Smékalová, Monika (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Jana Marková Title of Thesis: Dosing of veterinary eye drops 1. The main purpose of this thesis was to find out, whether and to what extent the rate of dispensing, the dispending angle (90ř, 65ř, 45ř) and the volume of preparation (30 ml, 15 ml, 5 ml) had effected the mass of commercial eye drops for poultry vaccination. Drops were produced manually by using conventional dispensing system (plastic 30 ml dropper bottle and dropper tip) and by using a new prototype of semi-automatic device. The drop mass increased with increasing the rate of drop formation in every examined combination of factors. With decreasing of the dispensing angle, the drop mass decreased only in a case of constant rate dropping. In all other cases, especially with volume reduction to 15 ml and 5 ml, the drop size often increased due to the wetting of hemispherical dropper tip. As a result, higher variability of drop masses had occurred. With using the semi-automated prototype, the preparation volume had no impact on the final drop mass. On the other hand, higher variability of doses was noted for studied suspension eye drops.
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Dosing of veterinary eye drops 2.
Chrapčiaková, Barbora ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Barbora Chrapčiaková Title of Thesis: Dosing of veterinary eye drops 2. In this thesis, the mass of veterinary eye drops for chicken vaccination was evaluated. Drops were produced either by conventional dosing system or by new developed dropper device (semi-automatic). The influence of dosing rate, dispensing angle (90ř, 65ř, 45ř) and volume of liquid (5 - 30 ml) on the mass of eye drop was investigated. The higher dosing rate resulted in the increase in drop mass. The influence of dosing rate on the mass of drop was significant (p < 0.01) for both dispensing systems. The drop mass decreased with the decrease in the dispensing angle using manual dosing system if the eye dropper tip was not wetted, with the wetted one, the drop mass increased in comparison to vertical dropping. Due to the construction of the dropper device, the influence of dispensing angle was not evaluated, however, the wetting of dropper tip was not observed thanks to defined perimeter. The reduction in the remaining preparation volume led to the decrease in drop weight, particularly with simultaneous dispensing angle decrease, the effect was not significant.
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